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In Alport syndrome AS a spectrum of phenotypes ranging from progressive renal disease with extrarenal abnormalities to isolated hematuria with a non-progressive or very slowly progressive course is observed. Hyman MD professor of pediatrics and division chief of developmental and behavioral pediatrics University of Rochester.
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Approximately two thirds of AS is X-linked XLAS.
. Approximately 15 is autosomal recessive ARAS and approximately 20 is autosomal dominant ADAS.
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